Global research indicates that at least one in ten adults over the age of 60 suffers from some degree of joint pain. Osteoarthritis is now a common cause of joint pain, resulting in disability for millions of adults worldwide. Fortunately, chondroitin, glucosamine, and MSM can provide rapid relief from joint pain. Studies have found that supplements containing chondroitin, glucosamine, and MSM offer significant protection for the cartilage and tissues of our joints. These three compounds possess potent antioxidant properties; furthermore, they are all natural, safe, and affordable. This article details chondroitin, glucosamine, and MSM, and their effects on our joints.