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bone and joint pain

Glucosamine and its use in joint pain

GlucosamineIt has been studied in numerous orthopedic experiments, including its effect on joint pain. However, most UK and Asian trials have focused more on the therapeutic effects of glucosamine on bone and joint pain. Today, many American adults have adoptedGlucosamine SulfateComeTreating Osteoarthritis, Because it can relieve pain, reduce tenderness and improve joint flexibility.

With reference to profound research on this subject, this article sorts to put in lay parlance, the role and methodology of glucosamine sulfate, and its anti-inflammatory effects on joints’ articular tissues. Further, an overview is also given to the scope and production forms of Glucosamine with final notes on its synergetic potentials as a combination therapy.

Glucosamine + Chondroitin

Discomfort in the knee and hip joints

Osteoarthritis is very common among people over the age of 50. Over time, studies have categorized different phenotypes of osteoarthritis, including obesity, mechanical, and aging. Osteoarthritis often occurs in the synovial joints in the body. A synovial joint is a type of joint that allows its bones to move smoothly relative to each other, such as the synovial joints on the extremities (shoulders, hips, elbows, and knees).

In addition, osteoarthritis is often accompanied by symptoms of severe pain, joint stiffness, and low joint mobility, mainly due to cartilage degeneration or its abnormal wear and tear loss. The role of cartilage is to restrain and cushion the mutual contact of bones in synovial joints. Arthralgia is the consequence of joint pain, stiffness and limited joint movement due to abnormal friction of cartilage that should have acted as a bone cushion.

Glucosamine sulfate only serves as a nutritional supplement and nonsteroidal, anti-inflammatory agent for cartilage repair and regeneration. So, how is this possible? Is there any difference between Glucosamine and Glucosamine sulfate? The next subheadings throw illuminating rays on the aforementioned questions and other misunderstandings surrounding the scope and use of Glucosamine.


Glucosamine and Glucosamine Sulfate: The Meanings, Their Roles, and Their Differences

First of all, glucosamine is a natural substance that exists in all major tissues of the human body, mainly concentrated in the connective tissue of the human body, especially cartilage tissue. For example, a synovial joint like the knee joint is composed of many parts, includingArticular cartilage and synovial fluid(joint fluid). Therefore, the substance "glucosamine" exists in large quantities in articular cartilage, intervertebral discs and synovial fluid between joints. It is scientifically believed that taking large amounts of glucosamine can help relieve symptoms of bone and joint pain due to its slow-acting effect on promoting cartilage and joint health. And many of these studies also suggest an anticatabolic mechanism of action for glucosamine.

However, for Glucosamine to be introduced into the body, it has to synthesize into absorbable forms. Glucosamine can be produced from the shells of lobster, crab, and shrimp. This means that Glucosamine can be extracted from the chitosan and chitin exoskeleton of crustaceans such as shellfish and maybe stabilized as a salt, glucosamine hydrochloride or glucosamine sulfate for oral administration. Simply put, Glucosamine sulfate is just a synthetized form of Glucosamine. Moreover, research also has it that humans can rapidly absorb up to 90 percent of Glucosamine into articular cartilage once administered as an oral dose of glucosamine sulfate.

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Application of Glucosamine Sulfate in Treatment of Osteoarthritis

Glucosamine can be used as a drug or nutraceutical after being extracted and stabilized by chemical processing. Numerous companies are now offering a number of reliable glucosamine sulfate nutritional supplements, offering patients suffering from bone and joint pain an alternative treatment option.

However, as far as the collective conclusions of clinical trials are concerned, most of the studies have hesitated to admit that glucosamine sulfate has a near-dramatic therapeutic effect on bone and joint pain, but they are not opposed to its use, because a large number of clinical data show that in the treatment of 30- After 90 days, the patient's condition improved to some extent.

So far, the use of glucosamine as a potential treatment option for osteoarthritis is still being refined. Some manufacturers thinkGlucosamine and chondroitinThe combined use may be more effective, because the two may have a synergistic effect in eliminating certain inflammation. On the other hand, some therapists suggest that glucosamine, exercise, and other medicines or health foods (such as Omega-3 fatty acids, calcium or manganese ascorbate) be used in combination. This is also because exercise helps to strengthen the muscles of the knees or hips and helps them to stand and walk easily.


There is evidence that glucosamine sulfate can help boneJoint painPatients relieve pain, reduce tenderness and improve joint flexibility. Nevertheless, it is undeniable that if only glucosamine sulfate is used as a monotherapy, its effect on improving joint structure and anti-inflammatory effects may be relatively slow. Therefore, the ideal approach is to combine non-pharmacological and pharmacological methods for treatment. This can ensure faster results, faster pain relief, and faster recovery.


  1. Da Camara CC, Dowless GV. Glucosamine sulfate for osteoarthritis. Ann Pharmacother. 1998; 32(5):580-587. doi:10.1345/aph.17214
  2. Matheson AJ, Perry CM. Glucosamine: a review of its use in the management of osteoarthritis. Drugs Aging. 2003; 20(14):1041-1060. doi:10.2165/00002512-200320140-00004
  3. Hochberg M. Chevalier X. Henrotin Y. et al. Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what's the evidence? Curr Med Res Opin. 2013; 29: 259-267
  4. Wandel S. Juni P. Tendal B. et al. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. Br Med J. 2010; 341: c4675
  5. Meulyzer M, Vachon P, Beaudry F, Vinardell T, Richard H, Beauchamp G, Laverty S: Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride. Osteoarthritis Cartilage. 2009, 17: 228-234. 10.1016/ j.joca.2008.06.018.
Michael Yeung
Author: Michael Yeung

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